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[Effect of somatostatin on peripheral circulation. Preliminary study]
Journal Des Maladies Vasculaires
|January 1, 1987
Summary
Synthetic somatostatin improved blood flow and reduced heart rate in subjects. This cyclic tetradecapeptide shows potential for treating circulatory conditions by affecting blood vessels.
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Context:
- Somatostatin, a cyclic tetradecapeptide, is prevalent in human cells with diverse physiological roles.
- Synthetic somatostatin is utilized in specific clinical contexts.
- Peripheral vascular function assessment involves rheography and plethysmography.
Purpose:
- To investigate the physiological effects of synthetic somatostatin administration on lower limb blood flow and heart rate in humans.
- To explore potential mechanisms underlying somatostatin's vascular and cardiac effects.
Summary:
- Synthetic somatostatin was administered intravenously to both healthy and arteriopathic individuals.
- Lower limb rheography and plethysmography were conducted pre-, during, and post-infusion.
- Significant enhancements in blood flow and reductions in heart rate were observed following somatostatin infusion.
Impact:
- The findings suggest somatostatin's potential therapeutic value in managing circulatory disorders.
- Hypotheses regarding somatostatin's mechanism of action include modulation of the sympathetic nervous system or calcium channel antagonism in blood vessels.