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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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The function of dendritic cells in modulating the host response.

L Song1,2, G Dong1, L Guo1,3

  • 1Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Molecular Oral Microbiology
|August 29, 2017
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) regulate adaptive immunity and periodontal disease. Deleting FOXO1 in DCs impairs their protective function, increasing susceptibility to periodontitis, highlighting the Akt-FOXO1 axis

Keywords:
FOXOacquired immunityforkheadgingivagingivitisimmune responselymphocyteperiodontal diseaseperiodontitis

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Area of Science:

  • Immunology
  • Oral Biology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial antigen-presenting cells initiating adaptive immune responses.
  • DCs orchestrate T-cell differentiation and are implicated in both protective and destructive roles in periodontal inflammation.
  • The transcription factor FOXO1 is vital for DC activation.

Purpose of the Study:

  • To investigate the role of FOXO1 in dendritic cell function during periodontal inflammation.
  • To explore the impact of lineage-specific FOXO1 deletion in DCs on periodontitis susceptibility.

Main Methods:

  • Utilized a mouse model with lineage-specific deletion of FOXO1 in dendritic cells.
  • Assessed the functional changes in DCs following FOXO1 deletion.
  • Evaluated the susceptibility to periodontitis in the modified mouse model.

Main Results:

  • Deletion of FOXO1 in DCs significantly reduced their protective function.
  • Mice with FOXO1-deficient DCs exhibited enhanced susceptibility to periodontitis.
  • The Akt-FOXO1 signaling pathway was identified as a key regulator.

Conclusions:

  • FOXO1 is essential for maintaining the protective functions of dendritic cells in the periodontium.
  • Dysregulation of the Akt-FOXO1 axis in DCs exacerbates periodontal disease.
  • Targeting the Akt-FOXO1 pathway in DCs may offer therapeutic strategies for periodontitis.