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Venipuncture procedure affects heart rate variability and chronotropic response.

Brian Kliszczewicz1, Michael R Esco2, Emily E Bechke1

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Pacing and Clinical Electrophysiology : PACE
|August 29, 2017
PubMed
Summary

Venipuncture significantly impacts heart rate variability (HRV) and heart rate (HR) for up to 10 minutes post-procedure. Researchers measuring HRV should consider this venipuncture effect.

Keywords:
autonomicsphlebotomyvagal tone

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Area of Science:

  • Physiology
  • Autonomic Nervous System Research
  • Cardiovascular Health

Background:

  • Heart rate variability (HRV) is influenced by various stressors, but its response to venipuncture is understudied.
  • Autonomic nervous system (ANS) responses during and after venipuncture are not well-characterized.

Purpose of the Study:

  • To investigate the acute effects of venipuncture on heart rate variability (HRV) indexes.
  • To examine heart rate (HR) changes during and after a venipuncture procedure in healthy individuals.

Main Methods:

  • 33 healthy participants underwent a 21-minute recording, including a 10-minute pre-venipuncture HRV baseline.
  • Venipuncture (1 minute) was followed by a 10-minute post-procedure HRV assessment.
  • Key HRV indexes (lnRMSSD, lnHF, lnLF, lnLF/HF) and HR were analyzed in pre- (PRE), venipuncture (STICK), and post- (POST) phases.

Main Results:

  • Heart rate (HR) significantly increased during venipuncture and decreased below resting levels 5 minutes post-procedure.
  • Significant increases in HRV indexes lnRMSSD and lnHF were observed post-venipuncture.
  • The lnLF/HF ratio significantly decreased post-venipuncture, indicating a shift in autonomic balance.

Conclusions:

  • Venipuncture acutely alters heart rate variability (HRV) and heart rate (HR) for at least 10 minutes.
  • These findings highlight the need for researchers and practitioners to account for venipuncture's influence when measuring HRV.