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Published on: September 20, 2019
Dedicated paediatric Outpatient Parenteral Antimicrobial Therapy medical support: a pre-post observational study
Ariel O Mace1, Charlie McLeod2, Daniel K Yeoh2
1Department of General Paediatrics, Princess Margaret Hospital for Children, Perth, Australia.
Insights
Introducing a dedicated medical team to paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT) improved patient monitoring and reduced hospital readmissions. This enhances care delivery in home-based settings.
Area of Science:
- Pediatric infectious diseases
- Health services research
Background:
- Paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT) offers benefits but carries risks.
- Evidence for mitigating these risks in home-based care is limited.
Purpose of the Study:
- To evaluate the impact of a dedicated medical team on paediatric OPAT outcomes.
- To define the role of enhanced medical oversight in improving patient safety and care.
Main Methods:
- Prospective observational cohort study over 24 months.
- Pre-post analysis of a Hospital in the Home (HiTH) programme.
- Inclusion of all non-haematology/oncology OPAT admissions.
Main Results:
- Improved adherence to monitoring guidelines (OR 4.90).
- Significantly reduced hospital readmissions (OR 0.45).
- Decreased proportion of prolonged OPAT (≥7 days) (OR 0.67).
Conclusions:
- A dedicated medical team positively impacted paediatric OPAT outcomes.
- Medical governance is crucial for nurse-led home-based services.
- Findings support structured medical oversight in paediatric OPAT.
Objective:
Despite the many benefits of paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT) programmes, there are risks associated with delivering inpatient-level care outside of hospital. There is a paucity of evidence defining how best to mitigate these risks. We examined the impact of introducing a dedicated medical team to OPAT, to define the role of increased medical oversight in improving patient outcomes in this cohort.
Design:
A prospective 24-month pre-post observational cohort study.
Setting:
The Hospital in the Home (HiTH) programme at Princess Margaret Hospital (PMH) for Children, Western Australia.
Patients:
All OPAT admissions to HiTH, excluding haematology/oncology patients.
Interventions:
PMH introduced a dedicated OPAT medical support team in July 2015 to improve adherence to best-practice guidelines for patient monitoring and review.
Main Outcome Measures:
Duration of OPAT, adherence to monitoring guidelines, drug-related and line-related adverse events and readmission to hospital.
Results:
There were a total of 502 OPAT episodes over 24 months, with 407 episodes included in analyses. Following the introduction of the OPAT medical team, adherence to monitoring guidelines improved (OR 4.90, 95% CI 2.48 to 9.66); significantly fewer patients required readmission to hospital (OR 0.45, 95% CI 0.24 to 0.86) and there was a significant reduction in the proportion of patients receiving prolonged (≥7 days) OPAT (OR 0.67, 95% CI 0.45 to 0.99).
Conclusion:
The introduction of a formal medical team to HiTH demonstrated a positive clinical impact on OPAT patients' outcomes. These findings support the ongoing utility of medical governance in a nurse-led HiTH service.
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