Related Experiment Video
Updated: Feb 23, 2026
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
The Hemodynamic Changes in Patients with Cerebral Arteriovenous Malformations before and after Interventional
Insights
Embolization therapy using Glubran 2 acrylic glue improved hemodynamics in cerebral arteriovenous malformations (CAVM) patients. Hemodynamic changes were linked to factors like Spetzler-Martin grade and malformation size.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Hemodynamics
Background:
- Cerebral arteriovenous malformations (CAVM) present complex hemodynamic challenges.
- Understanding hemodynamic alterations is crucial for effective treatment planning.
Purpose of the Study:
- To investigate hemodynamic changes in CAVM patients post-embolization with Glubran 2.
- To identify factors influencing these hemodynamic shifts.
Main Methods:
- Endovascular embolization using Glubran 2 acrylic glue was performed on CAVM patients.
- Hemodynamic parameters including blood pressure, blood flow velocity, and pulsatility index were measured.
- Vessel location, Spetzler-Martin grade, size, and vascular supply/drainage patterns were analyzed.
Main Results:
- Post-embolization, patients showed improved blood pressure and pulsatility index, with decreased blood flow velocity.
- Factors such as large CAVM size, high Spetzler-Martin grade, deep location, and specific drainage patterns correlated with altered hemodynamics.
- Hypertension was associated with lower hemodynamic parameters both pre- and post-treatment.
Conclusions:
- Glubran 2 embolization effectively enhances hemodynamics in CAVM patients.
- Hemodynamic outcomes are significantly influenced by Spetzler-Martin grade, CAVM size, and malformed vessel location.
Abstract:
The study explored hemodynamic changes in patients with cerebral arteriovenous malformations (CAVM) before and -after interventional embolization therapy with Glubran 2 acrylic glue and analyzed the related factors. CAVM patients received endovascular embolization therapy with Glubran 2. Patients' systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), blood flow velocity (BFV), and pulsatility index (PI) were measured. The location of malformed vessels, Spetzler-Martin (SM) grade, CAVM size, and type of feeding artery and venous drainage were analyzed. CAVM patients showed increased DBP, SBP, MAP, and PI and decreased average BFV compared to before therapy. CAVM patients with big CAVM size, SM grade IV/V, deep location malformed vessels, deep, and mixed venous drainage, and cortical branch and mixed artery blood-supply exhibited lower DBP, SBP, MAP, and PI but higher average BFV. Hypertensive CAVM patients showed lower DBP, SBP, MAP, average BFV, and PI before or after embolization. Hypertension, SM grade, CAVM size, malformed vessels location, venous drainage, and artery blood-supply were correlated to the hemodynamic changes of CAVM patients. Embolization with Glubran 2 acrylic glue could enhance hemodynamics in CAVM patients, and the hemodynamic changes were in correlation with the SM grade, CAVM size, and malformed vessels location.
More Related Videos
08:05Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
09:11Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats
Published on: September 17, 2014