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Related Concept Videos

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Sarcoidosis and Thyroid Autoimmunity.

Piera Fazzi1, Poupak Fallahi1, Silvia Martina Ferrari1

  • 1Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Frontiers in Endocrinology
|August 30, 2017
PubMed
Summary
This summary is machine-generated.

Female patients with sarcoidosis have an increased risk of thyroid autoimmunity and hypothyroidism. Early screening with thyroid function tests and ultrasonography is recommended for high-risk individuals.

Keywords:
Graves’ diseaseantithyroid peroxidase antibodiesautoimmune thyroiditishypothyroidismsarcoidosisthyroglobulin antibodies

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Area of Science:

  • Endocrinology
  • Rheumatology
  • Immunology

Background:

  • Sarcoidosis (S) is associated with a higher risk of thyroid dysfunction, particularly in women.
  • Studies indicate increased prevalence of hypothyroidism and thyroid autoimmunity in female sarcoidosis patients.

Purpose of the Study:

  • To investigate the association between sarcoidosis and thyroid autoimmunity.
  • To identify risk factors for thyroid dysfunction in female sarcoidosis patients.
  • To recommend screening and management strategies.

Main Methods:

  • Review of existing studies on sarcoidosis and thyroid autoimmunity.
  • Analysis of prevalence data for hypothyroidism, Graves' disease, and antithyroid antibodies (TPOAb).
  • Evaluation of Gallium-67 (Ga-67) scyntigraphy findings in relation to thyroid health.

Main Results:

  • Female sarcoidosis patients exhibit a higher risk of subclinical/clinical hypothyroidism, TPOAb, and general thyroid autoimmunity.
  • A higher prevalence of clinical hypothyroidism and Graves' disease was observed in female S patients compared to controls.
  • Thyroid uptake on Ga-67 scyntigraphy suggests aggressive autoimmune thyroiditis and hypothyroidism.

Conclusions:

  • Female sarcoidosis patients require assessment of thyroid function, TPOAb levels, and thyroid ultrasonography.
  • High-risk individuals (female, TPOAb positive, hypoechoic/small thyroid) need periodic thyroid function evaluation and treatment.