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Swiss Army Pathogen: The Salmonella Entry Toolkit.
Peter J Hume1, Vikash Singh1, Anthony C Davidson1
1Department of Pathology, University of CambridgeCambridge, United Kingdom.
Frontiers in Cellular and Infection Microbiology
|August 30, 2017
Summary
Salmonella invades host cells using a Type 3 Secretion System (T3SS) and other mechanisms. Understanding these invasion strategies and host cell signaling is crucial for combating salmonellosis.
Area of Science:
- Microbiology
- Cell Biology
- Immunology
Background:
- Salmonellosis is a global health concern causing significant morbidity and mortality.
- Pathogenic Salmonella strains possess the ability to invade non-phagocytic host cells, a critical step in disease development.
Purpose of the Study:
- To review the mechanisms employed by Salmonella for host cell invasion.
- To highlight the role of the Type 3 Secretion System (T3SS) and T3SS-independent pathways in Salmonella entry.
- To focus on the host cell signaling networks manipulated by Salmonella during invasion.
Main Methods:
- This review synthesizes existing research on Salmonella invasion mechanisms.
- It focuses on the molecular and cellular processes involved in pathogen entry.
- Analysis of host signaling pathways exploited by Salmonella.
Main Results:
- The Type 3 Secretion System (T3SS) is a primary determinant of Salmonella invasiveness, injecting effector proteins into host cells.
- Salmonella utilizes both T3SS-dependent and T3SS-independent strategies for host cell entry.
- Successful invasion relies on the coordinated manipulation of multiple host cell signaling pathways.
Conclusions:
- Understanding Salmonella's diverse invasion strategies and host cell interactions is essential for developing effective control measures.
- Targeting T3SS and host signaling pathways presents potential therapeutic avenues against salmonellosis.
