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Updated: Feb 23, 2026
08:00
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
19.4K
Skin toxicities associated with tumor treating fields: case based review.
Rimas V Lukas1, Kelley L Ratermann2, Eric T Wong3
1Department of Neurology, Northwestern University, Chicago, IL, USA.
Journal of Neuro-Oncology
|August 30, 2017
Summary
Tumor Treating Fields (TTFields) show promise for glioblastoma treatment, improving survival when combined with standard therapies. While skin toxicity is common, preventative measures can mitigate this adverse event.
Area of Science:
- Oncology
- Medical Devices
- Radiation Oncology
Background:
- Tumor Treating Fields (TTFields) represent a novel anti-mitotic therapy.
- TTFields, delivered via the Novo TTF-100A device (Optune), are FDA-approved for recurrent glioblastoma.
- A recent Phase III trial demonstrated improved survival when TTFields were combined with temozolomide, radiation, and chemotherapy in newly diagnosed glioblastoma.
Observation:
- The most frequent adverse event associated with TTFields is dermatologic toxicity.
- Headaches were observed, but their incidence was similar between treatment arms in a key trial.
- This case review examines patient presentations, treatments, and outcomes related to TTFields therapy.
Findings:
- Preventative strategies and patient/operator education can significantly reduce the incidence of TTFields-related skin toxicity.
- The safety profile of TTFields when used concurrently with other agents like bevacizumab requires further investigation.
Implications:
- Wider adoption of TTFields for glioblastoma is anticipated.
- Understanding and managing dermatologic adverse events is crucial for optimizing TTFields therapy.
- Further research is needed to assess the safety and efficacy of TTFields in combination with novel therapeutic agents.
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