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A Ernst1, P Schlattmann1, F Waldfahrer2

  • 1HNO-Klinik im ukb.

Laryngo- Rhino- Otologie
|August 30, 2017
PubMed
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The BEMED study found that betahistine did not significantly reduce vertigo attacks in Menière's disease patients compared to placebo. This critical discussion examines the study

Area of Science:

  • Otolaryngology
  • Neurology
  • Clinical Pharmacology

Background:

  • Menière's disease is a disorder of the inner ear.
  • Betahistine is commonly prescribed for Menière's disease symptoms.
  • Evidence supporting betahistine's efficacy remains debated.

Purpose of the Study:

  • To critically evaluate the BEMED study.
  • To assess the efficacy of betahistine in Menière's disease.
  • To compare low-level versus high-level betahistine dosage against placebo.

Main Methods:

  • Multi-centric, double-blind, placebo-controlled trial.
  • Inclusion of patients diagnosed with Menière's disease.
  • Primary endpoint: number of vertigo attacks > 20 minutes, patient diary documented.

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Main Results:

  • Betahistine showed no significant reduction in vertigo attacks compared to placebo.
  • No significant difference observed between low-level and high-level betahistine dosages.
  • The study did not support betahistine's effectiveness for Menière's disease.

Conclusions:

  • The BEMED study provides critical evidence against the routine use of betahistine.
  • Further research may be needed to clarify betahistine's role, if any.
  • This paper discusses the implications of the BEMED study findings.