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Age-dependent reference intervals for estimated and measured glomerular filtration rate.
Hans Pottel1, Pierre Delanaye2, Laurent Weekers2
1Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
Clinical Kidney Journal
|August 31, 2017
Summary
New equations using serum creatinine reference limits can define age-dependent glomerular filtration rate (GFR) reference intervals. This approach accurately reflects measured GFR (mGFR) in potential kidney donors.
Area of Science:
- Nephrology
- Clinical Chemistry
- Biostatistics
Background:
- Establishing accurate reference intervals for glomerular filtration rate (GFR) is challenging due to age-related decline and conflicting data.
- Traditional GFR reference values for young adults may be overestimated based on recent studies.
- Limited data exists for GFR reference intervals in individuals over 70 years old.
Purpose of the Study:
- To develop simple, age-dependent equations for GFR reference limits.
- To utilize serum creatinine (SCr) reference intervals and the full-age spectrum (FAS) equation for defining GFR reference limits.
- To validate these new formulae using measured GFR (mGFR) data from living kidney donors.
Main Methods:
- Defined age-dependent equations for GFR reference limits based on SCr reference intervals and the FAS equation.
- Validated the proposed formulae using mGFR data from 633 living potential kidney donors.
Main Results:
- Estimated GFR (eGFR) reference limits derived from SCr reference limits closely matched published mGFR reference limits.
- The newly defined GFR reference limits encompassed 97.2% of the mGFR values from potential living kidney donors.
Conclusions:
- Serum creatinine (SCr) reference limits can effectively establish age-dependent reference intervals for both estimated GFR (eGFR) and measured GFR (mGFR).
- The developed equations provide a reliable method for defining GFR reference ranges across different age groups.
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