Prostatic Urethral Lift Versus Transurethral Resection of the Prostate (TURP)

Lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE) represent one of the most common bothersome conditions impairing quality of life in men. Its management comprises conservative treatment, pharmacotherapy, and various surgical techniques. Medication and surgical procedures provide meaningful relief of LUTS, but their therapeutic efficacy has to be counterbalanced against the associated adverse events and morbidity. With the advent of novel minimally invasive treatment options, the surgical standards are challenged for at least equally effective approaches with a much more favorable safety profile. Clinical randomized controlled trials confirmed that PUL is able to provide rapid and durable relief of LUTS without compromising sexual function. However, in order to define the value and true benefit of a novel technique among established surgical procedures, the direct comparison with the reference method TURP is necessary. This was the main objective of the BPH6 study, which evaluated symptom relief, recovery experience, sexual function, urinary continence, and safety of PUL compared to TURP. Over a 2-year follow-up, no relevant negative impact on erectile function, urinary continence, and treatment-related safety was observed for both procedures. Improvement of LUTS was better after TURP, whereas PUL turned out to be superior in terms of quality of recovery, ejaculatory function, and quality of sleep. PUL can be considered in selected patients with bothersome LUTS, with special interest in the complete preservation of sexual function and a rapid and smooth return to daily activity.