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Involvement of Semaphorin (Sema4D) in T-Dependent Activation of B Cells

Е М Kuklina1, I V Nekrasova2, Yu V Valieva2

  • 1Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia. ibis_07@mail.ru.

Bulletin of Experimental Biology and Medicine
|August 31, 2017
PubMed

The involvement of endogenous semaphorin (Sema4D) into the key stage of T-dependent differentiation of B cells, formation of plasmoblasts, was demonstrated in vitro in T/B cell co-culture under conditions of polyclonal activation of T cells. The effect of semaphorin was not associated with activation of high-affinity Sema4D receptor plexin B1, but involves lowaffinity receptor CD72. These data indicate that Sema4D-dependent signal regulates not only the initial stage of B-cell activation, proliferative response to the antigen, but also further differentiation of B cells into plasma cells.

Keywords:
Sema4Ddifferentiation of B cellsplasmablasts

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