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Increased monocyte-to-HDL cholesterol ratio is related to cardiac syndrome X

Adnan Dogan1, Muhammed Oylumlu1

  • 1a Department of Cardiology , Dumlupinar University School of Medicine , Kutahya , Turkey.

Acta Cardiologica
|August 31, 2017
PubMed

Insights

Cardiac Syndrome X (CSX) is linked to a higher monocyte-to-HDL cholesterol ratio (MHR), an inflammation marker. This new marker may aid in predicting CSX, offering a cost-effective addition to existing methods.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Cardiac Syndrome X (CSX) is characterized by angina-like chest pain and evidence of ischemia without coronary artery stenosis.
  • Current diagnostic methods for CSX include exercise tests and myocardial perfusion scintigraphy.
  • The role of inflammation in CSX pathogenesis is increasingly recognized.

Purpose of the Study:

  • To investigate the association between Cardiac Syndrome X (CSX) and the monocyte-to-HDL cholesterol ratio (MHR).
  • To evaluate MHR as a potential novel biomarker for CSX.
  • To explore the relationship between MHR and other hematological parameters in CSX patients.

Main Methods:

  • A study included 230 participants: 105 with CSX and 125 healthy controls.
  • Peripheral venous blood samples were collected before coronary angiography.
  • Monocyte-to-HDL cholesterol ratio (MHR) and other hematological parameters were measured.

Main Results:

  • Patients with CSX exhibited significantly higher monocyte counts and MHR compared to controls.
  • HDL-cholesterol levels were significantly lower in the CSX group.
  • Elevated MHR and plateletcrit (PCT) were independently associated with the presence of CSX.

Conclusions:

  • Elevated MHR is independently associated with the presence of Cardiac Syndrome X.
  • MHR may serve as a valuable, cost-effective biomarker for CSX prediction.
  • This finding suggests MHR can complement existing diagnostic approaches for CSX.
Abstract

Keywords:
Cardiac syndrome Xinflammation markersmonocyte-to-HDL cholesterol ratio

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