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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Noncoding RNAs in neurodegeneration.

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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • The genome's regulation of brain function is complex and not fully understood.
  • Non-protein-coding RNAs (ncRNAs) play intricate roles in the central nervous system (CNS).
  • ncRNAs are implicated in neurodevelopment, brain aging, synapse function, and cognitive performance.

Purpose of the Study:

  • To provide an overview of ncRNA mechanisms in neurodegeneration.
  • To highlight the role of ncRNAs in brain health and disease.
  • To explore the potential of ncRNAs for novel diagnostic and therapeutic tools.

Main Methods:

  • Literature review of ncRNA functions in the CNS.
  • Analysis of ncRNA involvement in neurodegenerative disease pathogenesis.
  • Synthesis of current understanding of ncRNA-mediated regulation.

Main Results:

  • ncRNAs are critical regulators of molecular processes in the CNS.
  • Dysregulation of ncRNAs is linked to neurodevelopment and aging.
  • ncRNA pathways are involved in the pathogenesis of neurodegenerative disorders.

Conclusions:

  • ncRNA complexity presents challenges to conventional genomic regulation models.
  • Further understanding of ncRNA mechanisms in neurodegeneration is crucial.
  • ncRNAs represent promising targets for future diagnostic and therapeutic interventions.