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Updated: Feb 23, 2026
Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
Polyglutamine spinocerebellar ataxias - from genes to potential treatments
Henry L Paulson1, Vikram G Shakkottai1, H Brent Clark2
1Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Abstract:
The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and SCA7) are caused by expansion of a glutamine-encoding CAG repeat in the affected gene. These SCAs represent a substantial portion of the polyglutamine neurodegenerative disorders and provide insight into this class of diseases as a whole. Recent years have seen considerable progress in deciphering the clinical, pathological, physiological and molecular aspects of the polyglutamine SCAs, with these advances establishing a solid base from which to pursue potential therapeutic approaches.
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