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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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MATERNAL AND NEONATAL OUTCOMES OF HISTOLOGICAL CHORIOAMNIONITIS
A N Ocheke1, I E Ocheke2, P A Agaba3
1Department of Obstetrics and Gynaecology,Faculty of Medical Sciences, University of Jos, Jos, Nigeria.
Journal of the West African College of Surgeons
|September 1, 2017
Summary
Histological chorioamnionitis (HCA) was found in 60.8% of pregnant women. This study found no adverse maternal or neonatal outcomes linked to HCA, suggesting further research is needed.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Pathology
Background:
- Clinical chorioamnionitis is a known risk factor for maternal and neonatal complications.
- The impact of histological chorioamnionitis on maternal and neonatal outcomes is less understood, particularly in certain regions.
Purpose of the Study:
- To investigate the association between histological chorioamnionitis and maternal and neonatal outcomes.
- To determine the incidence of histological chorioamnionitis in the study population.
Main Methods:
- A cross-sectional longitudinal study was conducted at Jos University Teaching Hospital, Nigeria.
- 148 parturients and their placentas were assessed for histological chorioamnionitis.
- Maternal and neonatal outcomes were monitored for six weeks postpartum.
Main Results:
- The incidence of histological chorioamnionitis was 60.8% (90 out of 148 women).
- Rates of premature delivery, low birth weight, neonatal sepsis, and puerperal sepsis were similar between women with and without histological chorioamnionitis.
- Specifically, 10% with HCA and 8.62% without HCA had premature delivery; 13.33% with HCA and 10.34% without HCA had low birth weight.
Conclusions:
- Histological chorioamnionitis did not demonstrate adverse maternal or neonatal effects in this study.
- Further research is recommended to explore the causes and implications of histological chorioamnionitis.
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