Related Experiment Video
Updated: Feb 23, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Implementation of the Surviving Sepsis Campaign guidelines
Vikramjit Mukherjee1, Laura Evans
1NYU School of Medicine, Bellevue Hospital Center, New York City, New York, USA.
Early sepsis recognition and treatment improve patient outcomes. Implementing Surviving Sepsis Campaign (SSC) bundles enhances bedside care, leading to better results and reduced healthcare costs.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Healthcare Quality Improvement
Background:
- Early identification and management of sepsis are crucial for improving patient outcomes.
- Despite evidence, implementing evidence-based sepsis therapies remains suboptimal.
- This review focuses on methods to enhance the bedside application of sepsis guidelines.
Purpose of the Study:
- To describe methods for improving the bedside application of evidence-based sepsis guidelines.
- To highlight the importance of early sepsis recognition and management.
- To address the gap in the suboptimal implementation of sepsis therapies.
Main Methods:
- Review of methods to improve bedside application of evidence-based guidelines.
- Focus on Surviving Sepsis Campaign (SSC) guidelines and their implementation.
- Utilizing practice improvement measures and bundle strategies.
Main Results:
- The Surviving Sepsis Campaign (SSC) has updated guidelines since 2004, with the latest in 2016.
- SSC guidelines are filtered into bundles to promote rapid behavior change.
- Successful implementation of SSC bundles is linked to improved patient outcomes and reduced healthcare spending.
Conclusions:
- Implementation of SSC bundles involves practice improvement measures.
- Hospitals using SSC bundles show improved outcomes and reduced healthcare costs.
- SSC bundle compliance is a mandated core measure by the Centers for Medicare and Medicaid Services (CMS).
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Pulmonary Embolism III: Nursing Management

