Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Full-wave rectification from a mixed electrical-chemical synapse.

K Graubard, D K Hartline

    Science (New York, N.Y.)
    |July 31, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Post-Diapause DNA Replication during Oogenesis in a Capital-Breeding Copepod.

    Integrative organismal biology (Oxford, England)·2023
    Same author

    Rapid Jumps and Bioluminescence Elicited by Controlled Hydrodynamic Stimuli in a Mesopelagic Copepod, Pleuromamma xiphias.

    The Biological bulletin·2017
    Same author

    Rapid conduction and the evolution of giant axons and myelinated fibers.

    Current biology : CB·2007
    Same author

    Temperature compensation in the escape response of a marine copepod, Calanus finmarchicus (Crustacea).

    The Biological bulletin·2005
    Same author

    Tiling of the body wall by multidendritic sensory neurons in Manduca sexta.

    The Journal of comparative neurology·2001
    Same author

    Neural network partitioning by NO and cGMP.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    In lobsters, pyloric neuron connections show an unusual inverted U-shaped function. Positive or negative voltage changes in the presynaptic neuron cause the postsynaptic neuron voltage to become negative.

    Area of Science:

    • Neuroscience
    • Computational Neuroscience
    • Marine Biology

    Background:

    • Electrical and chemical synapses typically work together to transmit neural signals.
    • The stomatogastric nervous system in crustaceans provides a model for studying neural circuit function.
    • Neuronal communication relies on the interplay between electrical and chemical signaling.

    Purpose of the Study:

    • To investigate the unique transfer function of the pyloric late-to-lateral pyloric (PL-to-LP) neuronal connection in lobsters.
    • To elucidate the mechanisms underlying the inverted U-shaped voltage transfer between PL and LP neurons.
    • To understand how electrical and chemical synaptic interactions shape neuronal output.

    Main Methods:

    • Electrophysiological recordings from PL and LP neurons in the lobster stomatogastric ganglion.

    Related Experiment Videos

  • Voltage clamp and current clamp techniques to manipulate membrane potentials.
  • Analysis of synaptic currents and voltage responses to characterize the transfer function.

    • Main Results:

    • The PL-to-LP neuronal connection exhibits an inverted U-shaped voltage transfer function.
    • Negative presynaptic voltage changes in PL primarily result in negative LP voltage via electrical coupling.
    • Positive presynaptic voltage changes in PL lead to net negative LP voltage due to dominant chemical inhibition overriding electrical coupling.

    Conclusions:

    • The PL-to-LP connection demonstrates a non-reciprocal and inhibitory interaction, deviating from typical excitatory synaptic reinforcement.
    • This unique synaptic arrangement contributes to the rhythmic activity patterns of the pyloric circuit.
    • The interplay between electrical and chemical inhibition provides a robust mechanism for generating specific neuronal outputs.