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Fading Signals: How Long Does Antigenicity in Immunohistochemical Staining Last?

Ann M John1, Heather M Holahan1, Parmvir Singh1

  • 1Department of Dermatopathology, Department of Dermatology, and Department of Pathology and Laboratory Medicine, Rutgers - New Jersey Medical School, Newark, NJ.

Skinmed
|September 2, 2017
PubMed
Abstract

No abstract available in PubMed .

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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