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Genetics-based manipulation of adipose tissue sympathetic innervation
Marie François1, Emily Qualls-Creekmore1, Hans-Rudolf Berthoud1
1Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.
Physiology & Behavior
|September 2, 2017
Summary
Targeting the nervous system
Area of Science:
- Metabolic health
- Obesity research
- Neuroscience
Background:
- Brown adipose tissue (BAT) and white adipose tissue (WAT) influence energy balance and metabolic health.
- Sympathetic nervous system (SNS) innervation is critical for adipose tissue function.
- Current neuromodulation strategies are limited by incomplete knowledge of peripheral nerve function.
Purpose of the Study:
- To map the anatomical and neurochemical details of the peripheral nervous system.
- To guide the development of targeted neuromodulation strategies for obesity and metabolic diseases.
- To advance the Stimulating Peripheral Activity to Relieve Conditions (SPARC) initiative.
Main Methods:
- Comprehensive mapping of peripheral nervous system in animal models.
- Investigating anatomical and neurochemical aspects of innervation.
- Utilizing opto- and chemogenetic techniques for functional specificity.
Main Results:
- Detailed mapping of peripheral nervous system components.
- Identification of function-specific neurons and nerves.
- Enhanced understanding of SNS and PSNS roles in adipose tissue.
Conclusions:
- Mapping peripheral nervous system is crucial for effective neuromodulation.
- Targeting SNS and PSNS offers potential for obesity and metabolic disease treatment.
- Advanced techniques like opto- and chemogenetics will refine neuromodulation specificity.
