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Updated: Feb 23, 2026
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Published on: August 9, 2024
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Pediatric conjunctival melanoma arising from a compound nevus
Katy C Liu1, Prithvi Mruthyunjaya2, Alan D Proia3
1Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Summary
This case study details a rare conjunctival melanoma in a 9-year-old girl. Early diagnosis and treatment are crucial, as conjunctival melanoma can be misdiagnosed as benign conjunctival nevi in children.
Area of Science:
- Ophthalmology
- Dermatology
- Pediatric Oncology
Background:
- Conjunctival nevi are common in children, often showing benign growth.
- Conjunctival melanoma is a rare but aggressive malignancy of the eye.
Observation:
- A 9-year-old girl presented with a growing pigmented conjunctival lesion.
- Examination revealed a raised, vascularized lesion at the temporal limbus.
- Optical coherence tomography excluded scleral invasion.
Findings:
- Histopathology confirmed conjunctival melanoma arising from a nevus.
- Malignant cells were positive for HMB-45 and Ki-67 markers.
- Systemic evaluation showed no evidence of metastasis.
Implications:
- This case highlights the challenge of differentiating conjunctival melanoma from benign nevi in pediatric patients.
- Increased awareness and vigilance are necessary for accurate diagnosis and timely management of pediatric conjunctival melanoma.
- Prompt surgical excision and follow-up are essential for favorable outcomes.
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