Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anesthetic Strategy, Functional Outcomes, and Infectious Complications After Mechanical Thrombectomy for Acute Ischemic Stroke.

Journal of clinical medicine·2026
Same author

Early treatment with ofatumumab increases the likelihood of stabilizing disease in patients with relapsing-remitting multiple sclerosis.

Archives of medical science : AMS·2026
Same author

Real-world effectiveness of onabotulinumtoxinA as first-line treatment in chronic migraine and sequential transition to anti-CGRP monoclonal antibodies: a retrospective multicenter study.

BMC neurology·2026
Same author

Cerebrolysin after Endovascular Thrombectomy in Stroke: 12‑Month Functional Outcomes in a Propensity‑Matched Cohort.

Translational stroke research·2026
Same author

Contrast-Associated Acute Kidney Injury After Thrombectomy for Ischemic Stroke: Prognostic Impact and CAN-REST Predictive Score.

Neurology·2026
Same author

Degree and pattern of atrophy in multiple sclerosis - a systematic review.

Neurologia i neurochirurgia polska·2026

Related Experiment Video

Updated: Feb 23, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.8K

Limbic encephalitis - a report of four cases.

Żanna Pastuszak1,2, Adam Stępień2, Kazimierz Tomczykiewicz2

  • 1Department of Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

Central-European Journal of Immunology
|September 2, 2017
PubMed
Summary

Limbic encephalitis (LE) is a paraneoplastic syndrome often linked to small cell lung cancer, presenting with cognitive decline and seizures. Early diagnosis and identification of onconeural antibodies are crucial for managing this neurological disorder.

Keywords:
limbic encephalitisonconeural antibodiesparaneoplastic neurologic syndromestumour

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K
A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

3.5K

Related Experiment Videos

Last Updated: Feb 23, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.8K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K
A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

3.5K

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Limbic encephalitis (LE) is frequently a paraneoplastic neurologic syndrome, where symptoms can manifest years before cancer diagnosis.
  • Small cell lung carcinoma is associated with nearly 50% of LE cases, though other cancers and autoimmune conditions can also be implicated.

Observation:

  • LE involves dysfunction of the limbic system, often accompanied by cerebellar, brainstem, and polyneuropathy abnormalities.
  • Key clinical symptoms include subacute cognitive impairment, seizures, mental distress, consciousness disturbances, and limb paresis.
  • MRI reveals medial temporal lobe hyperintensities, EEG shows temporal sharp/slow waves, and CSF analysis may indicate pleocytosis and elevated protein/immunoglobulin levels.

Findings:

  • The majority of paraneoplastic LE patients exhibit onconeural antibodies in their blood.
  • This study details the clinical course of four patients diagnosed with limbic encephalitis.

Implications:

  • Understanding the diverse etiologies and clinical presentations of LE is vital for timely diagnosis and treatment.
  • Identifying onconeural antibodies aids in diagnosing paraneoplastic LE and guiding oncological management.
  • Further research into paraneoplastic syndromes can improve patient outcomes and therapeutic strategies.