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Options for Synthetic DNA Order Screening, Revisited
Diane DiEuliis1, Sarah R Carter2, Gigi Kwik Gronvall3
1Center for the Study of Weapons of Mass Destruction, National Defense University, U.S. Department of Defense, Washington, DC, USA.
Msphere
|September 2, 2017
Summary
Gene synthesis providers screen DNA orders for safety, but face challenges. This article suggests actions to maintain screening effectiveness and enhance DNA synthesis security.
Area of Science:
- Biosecurity
- Synthetic Biology
- Molecular Biology
Background:
- International Gene Synthesis Consortium (IGSC) members voluntarily screen DNA synthesis orders (>200 bp) for pathogens and customer vetting.
- Concerns exist regarding the ongoing feasibility and effectiveness of current screening practices.
- Technical limitations (e.g., unscreened DNA fragments <200 bp) and rising screening costs pose challenges.
Purpose of the Study:
- To evaluate the current state of DNA synthesis screening.
- To propose actionable strategies for preserving and enhancing biosecurity in gene synthesis.
- To explore supplementary security mechanisms for DNA synthesis technologies.
Main Methods:
- Analysis of technical and corporate challenges in DNA synthesis screening.
- Review of existing security protocols within the International Gene Synthesis Consortium (IGSC).
- Formulation of recommendations for improving DNA order screening and overall technology safety.
Main Results:
- DNA order screening, while imperfect, remains a valuable security tool.
- Technical and economic factors impact the efficiency of current screening methods.
- Additional security measures are necessary to complement existing screening protocols.
Conclusions:
- Despite challenges, DNA synthesis screening can remain effective with strategic adjustments.
- Implementing tangible actions is crucial for maintaining biosecurity in gene synthesis.
- A multi-faceted approach is needed to ensure the safety and security of advanced DNA synthesis technologies.
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