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Updated: Feb 23, 2026
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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
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Gut microbiota and physiologic bowel 18F-FDG uptake.
Ji Yeon Kang1, Han-Na Kim2, Yoosoo Chang3
1Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
EJNMMI Research
|September 2, 2017
Summary
Physiologic bowel FDG uptake in healthy individuals is linked to gut bacteria. Specific microbial changes, like low unclassified Clostridiales or high Klebsiella, correlate with varying FDG patterns.
Area of Science:
- Nuclear Medicine
- Microbiology
- Gastroenterology
Background:
- Physiologic bowel 18F-FDG uptake exhibits significant inter-individual variability.
- The underlying causes of normal intestinal 18F-FDG activity are not well understood.
Purpose of the Study:
- To explore the relationship between gut microbiota composition and physiologic bowel 18F-FDG uptake in healthy individuals.
- To identify specific microbial taxa associated with different patterns of bowel 18F-FDG accumulation.
Main Methods:
- 63 healthy males underwent 18F-FDG PET/CT scans and provided fecal samples.
- Gut microbiota were analyzed using 16S rRNA gene pyrosequencing.
- Generalized linear models identified associations between microbial genera and FDG uptake metrics (TBRmax, TBRmean).
Main Results:
- Focal or intense bowel 18F-FDG uptake was associated with lower abundance of unclassified Clostridiales.
- Lower-than-liver bowel FDG uptake correlated with higher abundance of Klebsiella.
- Total bowel to liver uptake ratios (TBRmax, TBRmean) showed a negative association with unclassified Enterobacteriaceae.
Conclusions:
- Physiologic bowel 18F-FDG activity may be influenced by gut microbiota composition.
- These findings suggest a potential link between gut barrier function and intestinal FDG uptake patterns.
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