Root resorptions associated with canine retraction treatment.

Area of Science:

• Orthodontics
• Dental Research
• Genetics

Background:

• External apical root resorption (EARR) is a recognized complication of orthodontic treatment.
• The exact multifactorial etiology of EARR remains incompletely understood.
• This study aimed to identify clinical factors contributing to EARR.

Purpose of the Study:

• To investigate the association between orthodontic treatment parameters and EARR.
• To explore the potential role of genetic factors in EARR.
• To identify clinical predictors of EARR.

Main Methods:

• Cone-beam computed tomography (CBCT) scans analyzed EARR in 18 subjects undergoing canine retraction.
• Standardized orthodontic forces (124-cN) and moment-to-force ratios were applied.
• Patient data including age, sex, treatment duration, and IL-1β rs11143634 genotype were collected.

Main Results:

• Six out of 18 subjects exhibited significant EARR, indicating multifactorial causes.
• All five subjects with available genotype data possessed the GG genotype for IL-1β rs11143634, suggesting a potential risk association.
• While not statistically significant, longer treatment duration, female sex, and older age showed trends towards increased EARR.

Conclusions:

• EARR is influenced by a combination of orthodontic load and individual patient factors.
• Genetic predisposition, particularly the IL-1β rs11143634 GG genotype, warrants further investigation.
• Future research should focus on the interplay between mechanical forces and genetic susceptibility in EARR.