In memory of Norman Bowery (1944-2016)
David G Trist1, Terry P Kenakin2, Thomas P Blackburn3
1Via Sauro 24, 37047 San Bonifacio, (VR), Italy.
Current Opinion in Pharmacology
|September 3, 2017
Summary
Professor Norman Bowery
Area of Science:
- Neuropharmacology
- Molecular Biology
- Neuroscience
Background:
- Research focuses on gamma-aminobutyric acid (GABA) pharmacology.
- Discovery of the novel metabotropic GABAB receptor subtype.
- Exploration of ionotropic GABAA receptors.
Discussion:
- Investigated neurotransmitters glutamate and substance P.
- Baclofen, a GABAB agonist, inhibits spinal cord neurotransmitter release.
- Examined therapeutic potential of GABAB receptor modulation.
Key Insights:
- GABAB receptors are pharmacologically and structurally distinct from GABAA receptors.
- GABAB receptor agonists show promise for treating spasticity, pain, and absence epilepsy.
- Professor Bowery's foundational work advanced GABAergic system understanding.
Outlook:
- Further research into GABAB receptor agonists for neurological disorders.
- Potential for novel therapeutics targeting GABAB pathways.
- Continued exploration of GABAergic system's role in central nervous system function.
