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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Tracheobronchopathy From Inhaled Corticosteroids.

Bryan C Husta1, Suhail Raoof1, Serpil Erzurum2

  • 1Lenox Hill Hospital, Hofstra Northwell School of Medicine, New York, NY.

Chest
|September 3, 2017
PubMed
Summary
This summary is machine-generated.

Inhaled corticosteroids (ICSs) are a primary treatment for asthma and are increasingly used for COPD. Their widespread adoption is due to their effectiveness and better safety compared to systemic steroids.

Keywords:
excessive dynamic airway collapseinhaled corticosteroidstracheobronchomalaciatracheomalacia

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Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Inhaled corticosteroids (ICSs) are the cornerstone of asthma management.
  • ICSs are also recommended for moderate to severe COPD patients experiencing recurrent exacerbations, often as add-on therapy.
  • The widespread clinical use of ICSs is driven by their established efficacy and a more favorable side effect profile compared to systemic corticosteroids.

Purpose of the Study:

  • To review the role of inhaled corticosteroids in respiratory disease management.
  • To highlight the clinical practice and evidence supporting ICS use in asthma and COPD.

Main Methods:

  • Literature review of clinical guidelines and studies on ICS use.
  • Analysis of efficacy and safety data for ICS in asthma and COPD.

Main Results:

  • ICS are highly effective for long-term asthma control.
  • Evidence supports ICS as an add-on therapy for specific COPD patient groups.
  • ICS demonstrate a superior safety profile relative to systemic steroids.

Conclusions:

  • Inhaled corticosteroids are essential for managing asthma and selected COPD cases.
  • The favorable safety and efficacy profile of ICS justify their widespread clinical application.