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An operant-based detection method for inferring tinnitus in mice.

Hongyan Zuo1, Debin Lei2, Shobhana Sivaramakrishnan3

  • 1Department of Anatomy and Neurobiology, Translational Research Center, Northeast Ohio Medical University, Rootstown, OH 44272, USA.

Journal of Neuroscience Methods
|September 3, 2017
PubMed
Summary

A new sound-based avoidance detection (SBAD) method accurately identifies acute and chronic tinnitus in mice. This validated approach enhances tinnitus research and potential therapeutic development.

Keywords:
Inferior colliculusMouse modelNoise-induced hearing lossOperant conditioningSodium salicylateTinnitus

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Area of Science:

  • Neuroscience
  • Auditory research
  • Animal models

Background:

  • Subjective tinnitus is a complex hearing disorder with incomplete understanding of its pathology.
  • Current treatments for tinnitus are limited due to incomplete knowledge of its underlying mechanisms.
  • Mouse models are crucial for investigating tinnitus pathophysiology and developing therapies.

Purpose of the Study:

  • To introduce a novel behavioral method for detecting tinnitus in mice.
  • To provide a reliable tool for studying both acute and chronic tinnitus.
  • To overcome limitations of existing methods in controlling for confounding factors.

Main Methods:

  • Developed the sound-based avoidance detection (SBAD) method for tinnitus detection in mice.
  • Utilized distinct paradigms within SBAD to assess tinnitus and potential confounding variables.
  • Validated SBAD findings through functional studies of neuronal activity.

Main Results:

  • The SBAD method successfully monitored both acute and chronic tinnitus in mice.
  • Functional validation confirmed increased neuronal activity in the inferior colliculus of mice identified with tinnitus.
  • SBAD demonstrated superior control over confounding factors compared to existing methods.

Conclusions:

  • Established a new, validated behavioral method for tinnitus detection in mice.
  • SBAD offers accurate tinnitus detection with enhanced control over confounding factors.
  • This method facilitates deeper understanding of tinnitus molecular pathways using genetic mouse models.