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Opposites attract in bispecific antibody engineering

Marit J van Gils1, Rogier W Sanders2,3

  • 1From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands and m.j.vangils@amc.uva.nl.

The Journal of Biological Chemistry
|September 3, 2017
PubMed
Summary

Bispecific antibodies can be improved for therapy by enhancing their heterodimerization. Specific electrostatic interactions were identified to create bispecific antibodies with better properties for treating diseases like cancer.

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