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Opposites attract in bispecific antibody engineering

Marit J van Gils1, Rogier W Sanders2,3

  • 1From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands and m.j.vangils@amc.uva.nl.

The Journal of Biological Chemistry
|September 3, 2017
PubMed

Bispecific antibodies show great promise as intrinsic combination therapies, but often suffer from poor physiochemical properties, many times related to poor heterodimerization. De Nardis et al. identify specific electrostatic interactions that facilitate efficient heterodimerization, resulting in bispecific antibodies with physiochemical properties very similar to those of naturally occurring antibodies. This provides a new platform for the treatment of an array of diseases from cancer and autoimmune diseases to infectious diseases.

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