Related Experiment Video
Updated: Feb 23, 2026
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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
Published on: February 7, 2021
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Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity.
Valsamo Anagnostou1, Mark Yarchoan1, Aaron R Hansen2
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Summary
Immuno-oncology clinical trials need new ways to measure drug success. Novel endpoints beyond traditional methods are crucial for effective immuno-oncology (I-O) drug development and patient care.
Area of Science:
- Oncology
- Immunology
- Clinical Trial Design
Background:
- Conventional toxicity and efficacy assessments are inadequate for immuno-oncology (I-O) therapies.
- Immune-targeted agents exhibit nonlinear dose-response and dose-toxicity kinetics.
- Established clinical trial paradigms must adapt to the unique characteristics of I-O.
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