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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Autoimmune Disorders01:29

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Updated: Feb 23, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Autoimmune progesterone dermatitis.

A Detrixhe1, A F Nikkels1, B Dezfoulian2

  • 1Dermato-allergology Unit, Department of Dermatology, Liège University Hospital, CHU du Sart Tilman, 4000, Liège, Belgium.

Archives of Gynecology and Obstetrics
|September 3, 2017
PubMed
Summary
This summary is machine-generated.

Autoimmune progesterone dermatitis (APD) is a rare condition in women of childbearing age. Diagnosis involves a progesterone skin test, and treatment may prevent future autoimmune diseases.

Keywords:
AutoimmunityIntradermal testPatch testPrick testProgesterone

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Area of Science:

  • Reproductive immunology
  • Dermatology
  • Endocrinology

Background:

  • Autoimmune progesterone dermatitis (APD) is an uncommon condition primarily affecting women of reproductive age.
  • It often manifests in the third decade of life and can be a precursor to other autoimmune conditions.

Purpose of the Study:

  • To present a case of autoimmune progesterone dermatitis (APD).
  • To highlight the diagnostic methods and long-term outcomes following treatment for APD.
  • To emphasize the importance of awareness among healthcare professionals.

Main Methods:

  • Diagnosis confirmed via intradermal skin testing with progesterone.
  • Testing performed during the follicular phase of the menstrual cycle.
  • A 6-year follow-up was conducted after curative treatment.

Main Results:

  • The presented case of APD was successfully treated.
  • No subsequent development of other autoimmune diseases was observed during the 6-year follow-up period.
  • This suggests that curative treatment may have long-term benefits.

Conclusions:

  • Autoimmune progesterone dermatitis (APD) is a rare but significantly debilitating condition.
  • Early diagnosis and treatment are crucial.
  • Healthcare providers should be vigilant for APD as an early sign of autoimmune disease.