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Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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Mechanisms of Membrane-bending01:15

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The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
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The Phragmoplast01:59

The Phragmoplast

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Cell division is essential for organismal growth and development. In animal cells, the central spindle and its associated proteins form the midbody, a structure that has an essential role in cytokinesis. In plants, the central spindle, along with the microtubules, actin, and other cell components, matures into the phragmoplast, which is necessary for cytokinesis. Unlike the stationary midbody, the phragmoplast expands centrifugally, eventually leading to the formation of the new cell wall.
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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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The Contractile Ring02:15

The Contractile Ring

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Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
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Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Related Experiment Video

Updated: Feb 23, 2026

Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

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Cell Shape Change by Drebrin.

Kensuke Hayashi1

  • 1Faculty of Science and Technology, Sophia University, 7-1, Kioicho, Chiyoda-ku, Tokyo, 102-8554, Japan. kensuk-h@sophia.ac.jp.

Advances in Experimental Medicine and Biology
|September 3, 2017
PubMed
Summary

Drebrin, a protein found in cells, regulates cell shape and actin-based activities. Its manipulation in neurons affects dendritic spine morphology and synaptic transmission.

Area of Science:

  • Cell Biology
  • Neuroscience
  • Cytoskeletal Dynamics

Background:

  • Drebrin is a protein localized in actin-rich cellular regions, including postsynaptic sites in mature neurons.
  • Its role in cellular functions necessitates understanding the consequences of its altered expression levels.

Purpose of the Study:

  • To investigate the functional roles of drebrin in various cell types by examining the effects of its overexpression or knockdown.
  • To elucidate drebrin's impact on neuronal morphology and synaptic function.

Main Methods:

  • Overexpression and knockdown of drebrin in diverse cell types (neurons, myoblasts, kidney cells, intestinal epithelial cells).
  • Analysis of cellular morphology, actin-based activities, dendritic spine structure, and postsynaptic receptor localization.
Keywords:
Axon elongationCell migrationDendrite formationDendritic spineDrebrin

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Main Results:

  • Alterations in cell shape and actin-based activities were observed across various cell types upon drebrin manipulation.
  • Drebrin manipulation in neurons led to changes in dendritic spine morphology, postsynaptic receptor distribution, and synaptic transmission.
  • Drebrin's effects are attributed to its actin-cross-linking activity and interactions with other cytoskeletal proteins and synaptic molecules.

Conclusions:

  • Drebrin is a multifunctional cytoskeletal regulator impacting cell shape, actin dynamics, and neuronal synaptic function.
  • Drebrin's interactions with actin and other proteins underscore its critical role in cellular architecture and neuronal communication.