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Chronobiologic Aspects of Venous Thromboembolism
Chiara Fantoni1, Francesco Dentali1, Walter Ageno1
1Department of Medicine and Surgery, Research Center on Thromboembolic Diseases and Antithrombotic Therapies, University of Insubria, Ospedale di Circolo, Via Guicciardini 9, Varese 21100, Italy.
Heart Failure Clinics
|September 4, 2017
Summary
This review explores the biological rhythms in venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Evidence suggests potential chronobiologic patterns, though mechanisms require further investigation.
Area of Science:
- Cardiovascular Medicine
- Chronobiology
- Thrombosis Research
Background:
- Cardiovascular diseases exhibit known chronobiologic patterns.
- Studies on venous thromboembolism (VTE) patterns show less consistent findings.
- VTE encompasses deep vein thrombosis and pulmonary embolism.
Purpose of the Study:
- To review evidence on chronobiologic aspects of VTE.
- To discuss potential underlying mechanisms for VTE patterns.
Main Methods:
- Literature review of studies on VTE occurrence and mortality.
- Analysis of proposed mechanisms for chronobiologic patterns in VTE.
Main Results:
- Inconsistent results exist regarding circadian and circannual patterns in VTE.
- Proposed mechanisms include coagulation protein oscillations, meteorologic factors, and air pollution.
Conclusions:
- Chronobiologic aspects of VTE require further research.
- Understanding these patterns may offer new insights into VTE prevention and treatment.
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