Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation
Keisuke Takai1, Shota Tanaka2, Takashi Sota1
1Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
World Neurosurgery
|September 4, 2017
Abstract
Background:
In 2016, the World Health Organization updated its classification of tumors, adding genetic profiles to the conventional histopathologic typing.
Case Description:
The authors present herein the first case of a 44-year-old female with isocitrate dehydrogenase-mutant World Health Organization grade II diffuse spinal astrocytoma diagnosed on the basis of both histopathologic and genetic findings.
Conclusions:
The present case underscores the significant role of a molecular genetic analysis in the differential diagnosis of intramedullary spinal gliomas.
