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Published on: May 27, 2015
Management around invasive procedures in mastocytosis: An update
Maud A W Hermans1, Nicolette J T Arends2, Roy Gerth van Wijk3
1Department of Internal Medicine, Section of Allergy, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Objective:
Mastocytosis is a chronic hematologic disorder that is characterized by the accumulation of aberrant mast cells and typically involves the skin and/or bone marrow. Patients with mastocytosis are at increased risk of anaphylaxis. Based on theoretical assumptions, medical procedures requiring general anesthesia or radiocontrast media are deemed hazardous for patients with mastocytosis. The objective of this article is to provide a comprehensive overview of the actual risk of iatrogenic anaphylaxis and provide recommendations for daily practice.
Data Sources:
Various scientific search engines were used (eg, PubMed and Medline).
Study Selections:
Because of the paucity of high-level studies on this topic, all available evidence was considered, including case reports.
Results:
Reliable data on the incidence of iatrogenic anaphylaxis in mastocytosis are lacking. However, although the incidence as reported in (retrospective) cohort studies is higher than in the general population, it is still lower than commonly anticipated, with an incidence of 5.4% in 1 study. Adequate premedication and avoidance of certain physical stimuli can further decrease this risk by 10-fold. The role of drugs as elicitors of anaphylaxis is perhaps overestimated, and physical stimuli are at least as important in inducing release of mast cell mediators.
Conclusion:
This article provides practical recommendations for the management of invasive procedures in patients with mastocytosis based on current knowledge of this topic.
