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Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and

Joy Wan1, Jack Steiner2, Eulalia Baselga3

  • 1Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA.

The Journal of Pediatrics
|September 5, 2017
PubMed
Summary

Prenatal risk factors like pre-eclampsia and placenta previa may be associated with PHACE syndrome, a rare condition. This study analyzed 218 patients to identify potential causes, finding increased rates of these conditions in affected individuals.

Keywords:
disease pathogenesishemangiomaperinatal risk factors

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Area of Science:

  • Medical Genetics
  • Obstetrics
  • Pediatrics

Background:

  • PHACE syndrome is a complex disorder with unknown etiology.
  • Identifying prenatal risk factors is crucial for understanding disease development.

Purpose of the Study:

  • To investigate potential prenatal risk factors for PHACE syndrome.
  • To compare the prevalence of specific obstetric conditions in PHACE syndrome patients versus the general population.

Main Methods:

  • Retrospective analysis of 218 patients diagnosed with PHACE syndrome.
  • Comparison of prenatal risk factor rates (pre-eclampsia, placenta previa) with general population data.

Main Results:

  • Significantly higher rates of pre-eclampsia were observed in individuals with PHACE syndrome.
  • Placenta previa was also found to be more prevalent in the PHACE syndrome cohort.
  • No significant sex-based differences in risk factors were detected.

Conclusions:

  • Prenatal factors, specifically pre-eclampsia and placenta previa, may play a role in the pathogenesis of PHACE syndrome.
  • Further research is warranted to elucidate the causal relationship between these obstetric complications and PHACE syndrome.