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Updated: Feb 23, 2026
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Drip-and-Ship Thrombolytic Therapy for Acute Ischemic Stroke
Ichiro Deguchi1, Satoko Mizuno1, Shinya Kohyama2
1Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan.
Summary
Drip-and-ship treatment systems facilitate timely neuroendovascular therapy for acute ischemic stroke patients. This approach, combining initial recombinant tissue plasminogen activator with subsequent advanced interventions, proves safe and effective for improving patient outcomes.
Area of Science:
- Neurology
- Interventional Radiology
Background:
- Acute ischemic stroke requires timely reperfusion therapy.
- Neuroendovascular therapy is crucial for anterior circulation strokes unresponsive to intravenous thrombolysis.
- A "drip-and-ship" model facilitates transfer of patients for advanced care.
Observation:
- A retrospective analysis of 16 "drip-and-ship" patients undergoing neuroendovascular therapy after initial recombinant tissue plasminogen activator treatment.
- Patient demographics and stroke etiologies (cardiogenic embolism, atherothrombosis) were recorded.
- Key time intervals including onset-to-recanalization were analyzed.
Findings:
- Neuroendovascular therapy was successfully performed in 14 patients.
- Mean onset-to-recanalization time was 334 minutes.
- No symptomatic intracranial hemorrhage occurred, indicating a safe treatment course.
Implications:
- Pre-transfer imaging (MRI/MRA) enables immediate reperfusion initiation post-transfer.
- The "drip-and-ship" model combined with neuroendovascular therapy is a viable and safe strategy for acute stroke management.
- This system expands access to critical neuroendovascular interventions for stroke patients.
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