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Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Updated: Jun 12, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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[Neuropathological Autopsies in Japan: Current Scenario and Challenges].

Masaki Takao1

  • 1Department of Clinical Laboratory and General Internal Medicine, National Center of Neurology and Psychiatry (NCNP) National Center Hospital.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

Autopsy-obtained brain tissue is vital for neurological disorder research. Declining autopsy rates necessitate collaboration with brain banks for tissue storage and utilization.

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Area of Science:

  • Neuropathology
  • Neuroscience research

Background:

  • Autopsy-derived central nervous system (CNS) tissue is crucial for understanding neurological disorders.
  • A decrease in autopsy rates limits the availability of essential human brain tissue for scientific study.

Purpose of the Study:

  • To highlight the importance of autopsy-derived brain tissue in neurological research.
  • To advocate for enhanced collaboration with brain banks.
  • To propose a system for proper storage, research use, and diagnostic analysis of nervous system tissues.

Main Methods:

  • Literature review on the role of autopsy tissue in neuroscience.
  • Analysis of trends in autopsy rates and their impact on research.
  • Conceptual framework development for brain bank collaboration.

Main Results:

  • The study underscores the irreplaceable role of post-mortem human brain tissue in advancing treatments and understanding neurological diseases.
  • Current trends indicate a significant reduction in tissue availability for critical research.

Conclusions:

  • Establishing robust collaborations with brain banks is imperative.
  • A systematic approach to managing autopsy-derived nervous system tissues is required to support ongoing and future research endeavors.