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Vitamin C Status and Cognitive Function: A Systematic Review.

Nikolaj Travica1, Karin Ried2, Avni Sali3

  • 1Centre for Human Psychopharmacology, Swinburne University of Technology, John St, Hawthorn, Melbourne 3122, Australia. ntravica@niim.com.au.

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Summary
This summary is machine-generated.

This review suggests higher vitamin C levels are linked to better cognitive function. However, more research is needed to confirm the association between vitamin C status and cognition in healthy adults.

Keywords:
Alzheimer’sMMSEascorbic acidcentral nervous systemcognitiondementiavitamin C

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Area of Science:

  • Neuroscience
  • Nutritional Science

Background:

  • Vitamin C is crucial for brain development and function, influencing neuronal systems.
  • Its role in cognitive performance requires further investigation.

Purpose of the Study:

  • To review the existing literature on the relationship between vitamin C status and cognitive performance.
  • To differentiate findings in cognitively intact versus impaired individuals.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, Scopus, etc.) from 1980 to 2017.
  • Included 50 studies: 5 RCTs, 24 prospective, 17 cross-sectional, and 4 case-control.
  • Assessed vitamin C status via dietary questionnaires or plasma levels and cognition using various tests, primarily the MMSE.

Main Results:

  • Cognitively intact individuals generally exhibited higher plasma vitamin C concentrations than impaired groups.
  • No significant correlation was found between vitamin C levels and MMSE scores in impaired individuals.
  • The MMSE was insufficient for detecting cognitive variations in healthy adults.

Conclusions:

  • A potential association exists between plasma vitamin C and cognitive function, particularly in healthy adults.
  • Limitations in current studies necessitate further research.
  • Future studies should use sensitive cognitive assessments and measure plasma vitamin C levels.