Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

8.3K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
8.3K
Blood Flow01:29

Blood Flow

77.0K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
77.0K
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

4.9K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
4.9K
Open and closed-loop control systems01:17

Open and closed-loop control systems

1.8K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.8K
Node Analysis for AC Circuits01:14

Node Analysis for AC Circuits

714
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
714
PID Controller01:19

PID Controller

787
Proportional-Integral-Derivative (PID) controllers are widely used in various control systems to enhance stability and performance. In a thermostat, it adjusts heating or cooling based on the temperature difference between the actual and desired levels. They are often used in automotive speed systems, effectively managing sudden speed changes while maintaining a constant speed under varying conditions. On the other hand, PI controllers, commonly employed in voltage regulation, enhance stability...
787

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Comprehensive Numerical Model of Thrombus Embolization: Fluid-Thrombus Interactions Through a Coupled Computational Fluid Dynamics - Peridynamics Framework.

Computer methods in applied mechanics and engineering·2026
Same author

Fibroblast-derived CCL2 orchestrates immune responses and defends against Staphylococcus aureus skin infection.

Cellular & molecular immunology·2026
Same author

Identification and characterization of a novel Plakoglobin-binding protein highly expressed in the testes.

Biochimica et biophysica acta. Molecular cell research·2026
Same author

Safety and efficacy of clofarabine for preconditioning intervention in patients undergoing allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute lymphoblastic leukemia.

International journal of hematology·2026
Same author

Geometry-Encoded Microtrenches Stabilize Endothelium on High Shear Biomaterial Surfaces.

bioRxiv : the preprint server for biology·2026
Same author

[Efficacy of fostamatinib add-on for TPO receptor agonist-refractory immune thrombocytopenia].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

Large-Eddy Simulation of the FDA Benchmark Blood Pump: Validation Against Experiments and Implications for Turbulent Flow Mechanisms.

Artificial organs·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
09:34

Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow

Published on: October 31, 2019

7.0K

Controller for an Axial Flow Blood Pump.

Hiroaki Konishi1, James F Antaki1, Devin V Amin1

  • 1University of Pittsburgh, Artificial. Heart and Lung Program, Schools of Medicine, Pittsburgh, PennsylvaniaUniversity of Pittsburgh, Artificial. Heart and Lung Program, Schools of Engineering, Pittsburgh, PennsylvaniaNimbus, Inc., Rancho Cordova, California, U.S.A.

Artificial Organs
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel control method for rotary blood pumps, using motor current harmonics to noninvasively regulate pump speed. This approach aims to prevent device-induced complications and maintain stable patient circulation without extra sensors.

Keywords:
Axial flow blood pump-Noninvasive pump regulation

More Related Videos

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators
08:59

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators

Published on: June 13, 2022

3.0K
Particle Image Velocimetry Investigation of Hemodynamics via Aortic Phantom
06:26

Particle Image Velocimetry Investigation of Hemodynamics via Aortic Phantom

Published on: February 25, 2022

4.9K

Related Experiment Videos

Last Updated: Feb 23, 2026

Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
09:34

Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow

Published on: October 31, 2019

7.0K
Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators
08:59

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators

Published on: June 13, 2022

3.0K
Particle Image Velocimetry Investigation of Hemodynamics via Aortic Phantom
06:26

Particle Image Velocimetry Investigation of Hemodynamics via Aortic Phantom

Published on: February 25, 2022

4.9K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Control Systems

Background:

  • Rotary blood pumps have limited noninvasive monitoring capabilities, with only motor current observable and pump speed controllable.
  • Maintaining adequate systemic circulation requires precise control of pump speed to balance flow, pressure, and preload, preventing organ damage.

Purpose of the Study:

  • To develop a noninvasive control method for rotary blood pumps that regulates pump speed based on motor current.
  • To avoid ventricular collapse and maintain physiologic preload by minimizing specific harmonic components of the pump current waveform.

Main Methods:

  • Collected steady-state data from Nimbus AxiPump trials in sheep and calves.
  • Increased pump speed to observe effects on left atrial pressure and evaluated preload changes via vena cava occlusion.
  • Utilized Fourier analysis to correlate pump current waveform power spectra with preload variations.

Main Results:

  • Established a relationship between pump preload changes and the power spectra of the pump current waveform.
  • Devised a control strategy focused on minimizing the second and third harmonics of the current waveform.
  • Demonstrated the potential for noninvasive regulation by eliminating the need for additional transducers.

Conclusions:

  • A novel control method using motor current harmonics can noninvasively regulate rotary blood pump speed.
  • This approach effectively maintains preload within a physiologic range, preventing adverse events like ventricular collapse.
  • The proposed method offers a simpler, transducer-free solution for blood pump control in clinical applications.