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Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

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V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
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Related Experiment Video

Updated: Feb 23, 2026

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

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Can We Develop a Nonpulsatile Permanent Rotary Blood Pump? Yes, We Can.

Yukihiko Nosé1, Koji Kawahito1, Tadashi Nakazawa1

  • 1Baylor College of Medicine, Department of Surgery, One Baylor Plaza, Houston, Texas, U.S.A.

Artificial Organs
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

Nonpulsatile blood pumps are as effective as pulsatile ones, showing no significant differences in clinical outcomes. These pumps offer simpler, more durable designs for advanced medical applications.

Keywords:
Nonpulsatile blood pumpRotary blood pump-

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Science
  • Medical Devices

Background:

  • Historically, nonpulsatile perfusion was believed to cause physiological and circulatory abnormalities.
  • This misconception has been challenged by research demonstrating the viability of nonpulsatile systems.

Purpose of the Study:

  • To evaluate the clinical efficacy and advantages of nonpulsatile blood pumps compared to pulsatile systems.
  • To highlight the design benefits and potential of nonpulsatile rotary blood pumps for permanent implantation.

Main Methods:

  • Experimental studies comparing circulatory and physiological parameters between pulsatile and nonpulsatile blood pumps.
  • Analysis of pump design, component requirements, and implantation procedures.

Main Results:

  • Nonpulsatile perfusion, with a 20% higher flow rate, showed no circulatory or physiological abnormalities.
  • No significant difference in clinical outcomes was observed between pulsatile and nonpulsatile blood pump use.
  • Nonpulsatile rotary blood pumps demonstrated reliable performance and offered design advantages like simplicity and ease of implantation.

Conclusions:

  • Nonpulsatile blood pumps are clinically equivalent to pulsatile pumps.
  • The design of nonpulsatile pumps offers significant advantages, including fewer thrombogenic components and simpler implantation.
  • Ongoing development focuses on creating a permanently implantable nonpulsatile assist device with specific desirable features.