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Updated: Feb 23, 2026

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
Published on: October 20, 2023
Main causes of hospitalization in people with Angelman syndrome
M Felícitas Domínguez-Berjón1, Ana Clara Zoni1, María D Esteban-Vasallo1
1Directorate-General for Public Health, Madrid Regional Health Authority, Madrid, Spain.
Background:
The objective was to describe the main causes of hospitalization in people with Angelman syndrome (AS).
Method:
Population-based cross-sectional study in the Community of Madrid (CM), Spain. The information source for AS cases was the information system for rare diseases in the CM. Variables related to hospitalization, for the period 2006-2014, were the following: number of episodes, outcome, main cause, length of stay and type of admission. Main causes of hospitalization were described by age group and sex.
Results:
The most frequent causes of hospitalization were the following: oral-dental care (28.9%), seizures (19.6%), orthopaedic problems (14.4%) and acute respiratory disorders (12.4%). The percentage of hospitalizations was higher for oral-dental care in women and for orthopaedic problems in men (p-value <.05). Hospitalizations for an acute respiratory disorder were higher in adults (p-value <.05).
Conclusions:
Some differences in the causes of hospitalization of people with AS were observed by sex and age.
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