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Updated: Feb 23, 2026

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
Published on: April 6, 2015
[Application of nanobody in cancer treatment]
Yue Wu1, Xiujing Hao1, Min Li1
1Key Laboratory for Conservation and Utilization of Special Biological Resources in the Western China, Ministry of Education, Ningxia University, Yinchuan 750021, Ningxia, China.
Abstract:
Camelidae can produce a unique antibody that lacks light chain called variable heavy chain domain, also known as nanobodies. This antibody contains only one variable region, with high affinity, high stability, strong tissue penetration, efficient expression. Besides, their toxicity and immunogenicity are both low to be used for both therapeutic and diagnostic applications, as well as research tools. In this review, we discuss how nanobody has been explored as therapeutics in oncology, and provide ideas for the further development of nanobody.
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