Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

18.9K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.9K
Cell Migration01:19

Cell Migration

6.8K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.8K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.6K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.6K
The Cochlea01:13

The Cochlea

51.6K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
51.6K
Hair Cells01:22

Hair Cells

45.6K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
45.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Cell Profiling of the Developing Organ of Corti Identifies Etv4/5/1 as Key Regulators of Pillar Cell Identity.

bioRxiv : the preprint server for biology·2026
Same author

Single cell analysis of developing Merkel cells reveals the emergence of non-coding RNA biotypes as a hallmark of terminal differentiation.

Cell death and differentiation·2026
Same author

CASZ1 regulates the rate at which outer hair cells mature and is required for hearing.

bioRxiv : the preprint server for biology·2025
Same author

Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea.

Cells·2025
Same author

Ectoderm barcoding reveals neural and cochlear compartmentalization.

Science (New York, N.Y.)·2025
Same author

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: Feb 23, 2026

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

4.3K

Cell migration, intercalation and growth regulate mammalian cochlear extension.

Elizabeth Carroll Driver1, Amy Northrop2, Matthew W Kelley2

  • 1Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA drivere@nidcd.nih.gov.

Development (Cambridge, England)
|September 6, 2017
PubMed
Summary
This summary is machine-generated.

Cochlear development extends through cell growth and intercalation. Myosin II regulates cell movement and protrusions, establishing sensory cell distribution along the tonotopic axis.

Keywords:
Cochlear developmentConvergent extensionInner earLive imagingMouseRadial intercalation

More Related Videos

Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs
08:17

Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs

Published on: June 1, 2018

8.7K
Long-term Time Lapse Imaging of Mouse Cochlear Explants
10:43

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

10.1K

Related Experiment Videos

Last Updated: Feb 23, 2026

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
08:08

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti

Published on: December 4, 2020

4.3K
Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs
08:17

Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs

Published on: June 1, 2018

8.7K
Long-term Time Lapse Imaging of Mouse Cochlear Explants
10:43

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

10.1K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Auditory Neuroscience

Background:

  • Cochlear sensory epithelium remodeling is crucial for auditory organ development.
  • The cellular mechanisms driving cochlear elongation and tonotopic organization remain largely unknown.

Purpose of the Study:

  • To elucidate the cellular processes underlying cochlear sensory epithelium remodeling in mice.
  • To identify the molecular regulators of cell behaviors during cochlear development.

Main Methods:

  • Morphological assessments of cellular rearrangements.
  • Time-lapse imaging of cochlear development in mouse models.
  • Analysis of cell redistribution, movement, and size changes.

Main Results:

  • Cochlear extension occurs via radial intercalation and cell growth.
  • Cellular intercalation leads to transient epithelial convergence, followed by medial-lateral spreading due to cell size changes.
  • Supporting cells exhibit directed movement and protrusion activity, while hair cells contribute to outgrowth via increased cell size.
  • Myosin II is essential for regulating cellular protrusions, movement, and intercalation.

Conclusions:

  • This study reveals key cellular mechanisms driving cochlear elongation and sensory cell patterning.
  • Myosin II plays a critical role in coordinating cell behaviors for tonotopic organization.
  • Provides a foundational understanding of the cellular basis for auditory system development.