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Stem Cell-based Therapies for Sepsis.

Colm Keane1, Mirjana Jerkic, John G Laffey

  • 1From the Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Ireland (C.K., J.G.L.); Department of Anesthesia, Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, Toronto, Ontario, Canada (M.J., J.G.L.); and Departments of Anesthesia, Physiology, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada (J.G.L.).

Anesthesiology
|September 6, 2017
PubMed
Summary
This summary is machine-generated.

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Mesenchymal stem cells show promise for treating sepsis, a life-threatening condition with high mortality. Research explores their potential mechanisms and clinical trial progress to overcome treatment barriers.

Area of Science:

  • Sepsis research
  • Stem cell therapy
  • Immunology

Background:

  • Sepsis is a critical condition with high mortality, characterized by immune dysregulation.
  • Current sepsis management is primarily supportive, lacking targeted treatments.
  • Stem cells, particularly mesenchymal stem/stromal cells (MSCs), are being investigated as potential therapeutics.

Purpose of the Study:

  • To review the rationale for using stem cells in sepsis treatment.
  • To focus on mesenchymal stem/stromal cells (MSCs) due to their therapeutic potential.
  • To evaluate preclinical evidence, mechanisms of action, and clinical trial status of MSCs for sepsis.

Main Methods:

  • Review of preclinical studies on stem cells for sepsis.
  • Analysis of proposed mechanisms of action for mesenchymal stem/stromal cells (MSCs).

Related Experiment Videos

  • Evaluation of early-phase clinical trials involving MSCs in sepsis patients.

    • Main Results:

    • Mesenchymal stem/stromal cells (MSCs) exhibit therapeutic potential in preclinical sepsis models.
    • Proposed mechanisms include immunomodulation and tissue repair.
    • Early clinical trials are underway, but translational challenges exist.

    Conclusions:

    • Mesenchymal stem/stromal cells (MSCs) represent a promising avenue for sepsis therapy.
    • Further research is needed to elucidate mechanisms and overcome barriers to clinical translation.
    • Clinical trials are essential to validate the efficacy and safety of MSCs for sepsis treatment.