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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Topical cannabinoids in dermatology.

Peter W Hashim1, Joel L Cohen2, David T Pompei3

  • 1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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Summary
This summary is machine-generated.

Topical cannabinoids are popular for skin issues, but scientific proof of their safety and effectiveness is lacking. This review examines current research on cannabinoids for dermatological conditions.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Topical cannabinoids are widely used by patients for various skin conditions.
  • Consumer acceptance of these over-the-counter products exceeds scientific validation.

Purpose of the Study:

  • To review existing studies on the use of topical cannabinoids in dermatology.
  • To assess the current evidence regarding the safety and efficacy of these agents in skin conditions.

Main Methods:

  • Literature review of scientific studies on topical cannabinoids and skin conditions.
  • Analysis of research data on safety and efficacy profiles.
  • Evaluation of the current role of topical cannabinoids in dermatological practice.

Main Results:

  • Limited scientific investigation into the safety and efficacy of topical cannabinoids.
  • Growing patient utilization of these products for diverse dermatological disorders.
  • Need for further rigorous research to support clinical use.

Conclusions:

  • The use of topical cannabinoids in dermatology is not yet supported by robust scientific evidence.
  • Further research is required to establish the safety and efficacy of these agents for specific skin conditions.
  • Clinical recommendations for topical cannabinoid use in dermatology are premature due to insufficient data.