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Synchronized RF and HIFES Technology for Clinically Significant Wrinkle Reduction: A Multicenter 3D Evaluation.

Chris W Robb¹, Joel L Cohen², Amanda Holden³

¹Skin & Allergy Center, Spring Hill, Tennessee, USA.

Journal of Cosmetic Dermatology

|August 13, 2025

Summary

This summary is machine-generated.

High-Intensity Focused Electrical Stimulation (HIFES) combined with radiofrequency (RF) significantly reduces wrinkles. This noninvasive treatment improves skin appearance and quality, with high patient satisfaction and comfort.

Keywords:

HIFES noninvasive radiofrequency wrinkle reduction antiaging

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Area of Science:

Aesthetic dermatology and cosmetic procedures.
Energy-based devices for skin rejuvenation.

Background:

Youthful skin is associated with health and well-being.
Noninvasive energy-based procedures are popular for targeting aging signs through controlled stimulation.

Purpose of the Study:

To evaluate High-Intensity Focused Electrical Stimulation (HIFES) combined with synchronized radiofrequency (RF) for noninvasive wrinkle treatment.

Main Methods:

Thirty-three patients received four HIFES and synchronized RF treatments.
Objective wrinkle assessment using 3D and 2D photography (GAIS, FWES).
Subjective patient outcomes via satisfaction and comfort surveys.

Main Results:

Significant wrinkle reduction observed, with 3D analysis showing up to 35.36% improvement at 3 months.
88% of participants showed improvement on the Global Aesthetic Improvement Scale (GAIS) at 3 months.
High patient satisfaction and comfort reported, with a shift in wrinkle severity classification.

Conclusions:

HIFES combined with synchronized RF is an effective noninvasive wrinkle treatment.
The procedure demonstrates objective efficacy and positive patient-reported outcomes.
Offers a safe and well-tolerated option for enhancing skin appearance and quality.