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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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[Drowning-induced hyperfibrinolytic disseminated intravascular coagulation].
Andreas Lund Hattesen1, Henrik Karsten Berg, Lars Folkersen
1am.hvas@dadlnet.dk.
Ugeskrift for Laeger
|September 7, 2017
Summary
Drowning can cause a dangerous bleeding disorder called hyperfibrinolytic disseminated intravascular coagulation. Prompt diagnosis and treatment with antifibrinolytics and fibrinogen are crucial for survival.
Area of Science:
- Emergency Medicine
- Hematology
Background:
- Drowning leads to respiratory failure, cardiac arrest, hypoxemia, and ischemia.
- These physiological disturbances trigger a coagulopathy.
- The clinical manifestation includes uncontrolled bleeding due to hyperfibrinolysis.
Purpose of the Study:
- To summarize current knowledge on drowning-induced hyperfibrinolytic disseminated intravascular coagulation.
- To highlight the importance of rapid diagnosis and treatment.
Main Methods:
- Literature review and synthesis of existing research on drowning and coagulopathy.
- Analysis of the pathophysiological mechanisms linking drowning to hyperfibrinolysis.
- Discussion of diagnostic criteria and therapeutic interventions.
Main Results:
- Drowning initiates a cascade of events including ischemia, acidosis, and hypothermia, leading to coagulopathy.
- Hyperfibrinolysis is a key feature, resulting in severe, uncontrolled bleeding.
- A specific diagnostic approach is necessary to identify this hyperfibrinolytic state.
Conclusions:
- Drowning-induced hyperfibrinolytic disseminated intravascular coagulation is a life-threatening condition.
- Early recognition and intervention with antifibrinolytics and fibrinogen concentrate are essential for patient survival.
- Further research into optimal management strategies is warranted.
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