Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.7K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.7K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.3K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.3K
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.3K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.3K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

7.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
7.9K
Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Memory Performance in Adolescents Living With Obesity: Brain Activation During Encoding and Retrieval in a Case-Control Study.

Obesity science & practice·2026
Same author

Prefrontal long-range somatostatin inhibitory projections modulate fear expression.

Frontiers in cellular neuroscience·2026
Same author

Prefrontal neural geometry of learned cues guides motivated behaviours.

Nature·2026
Same author

Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Noradrenergic modulation of pheromone-induced odor learning and brain activation in newborn rabbits.

Scientific reports·2025
Same author

Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system.

Current biology : CB·2025

Related Experiment Video

Updated: Feb 23, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.9K

Temporal binding function of dorsal CA1 is critical for declarative memory formation.

Azza Sellami1,2, Alice Shaam Al Abed1,2, Laurent Brayda-Bruno1,2

  • 1Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U1215, INSERM, F-33000 Bordeaux, France.

Proceedings of the National Academy of Sciences of the United States of America
|September 7, 2017
PubMed
Summary

Temporal binding, crucial for linking events in memory, is necessary for relational organization. Its decline in aging, linked to dorsal CA1 activity, causes age-related memory impairment.

Keywords:
agingoptogeneticsradial mazerelational memorytrace conditioning

More Related Videos

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

8.5K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

Related Experiment Videos

Last Updated: Feb 23, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.9K
Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

8.5K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Aging Research

Background:

  • Temporal binding and relational organization are hippocampus-dependent memory processes.
  • Both processes decline with aging, but their relationship and impact on memory loss are unclear.

Purpose of the Study:

  • To investigate the relationship between temporal binding and relational organization in declarative memory.
  • To understand how these processes are affected by aging and contribute to memory impairment.

Main Methods:

  • Investigated the causal link between temporal binding and relational organization.
  • Examined the role of dorsal CA1 activity in temporal binding over time intervals.
  • Assessed memory performance in aging individuals under varying temporal binding demands.

Main Results:

  • Temporal binding is a prerequisite for relational organization of discontiguous events.
  • Dorsal CA1 activity over time intervals is critical for temporal binding and diminishes in aging.
  • Relational memory formation is successful in aged individuals when temporal binding demands are minimized.

Conclusions:

  • Dorsal CA1-mediated temporal binding is foundational for relational representation.
  • Deterioration of temporal binding mechanisms in aging is responsible for age-associated memory impairment.
  • Relational/declarative memory itself is not impaired in aging, but relies on intact temporal binding.