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Immune Cell Metabolism in Tumor Microenvironment.
Yongsheng Li1, Yisong Y Wan2, Bo Zhu3
1Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Advances in Experimental Medicine and Biology
|September 7, 2017
Summary
Metabolic reprogramming in the tumor microenvironment (TME) alters immune cell function. Understanding these changes in cancer metabolism offers new therapeutic strategies for cancer treatment.
Area of Science:
- Immunology
- Cancer Biology
- Metabolism
Background:
- The tumor microenvironment (TME) is a complex ecosystem involving tumor cells, immune cells, and the extracellular matrix.
- Immune and metabolic systems are intricately linked in cancer development and progression.
- Metabolic reprogramming of immune and cancer cells within the TME significantly influences tumor immunology.
Purpose of the Study:
- To provide an updated understanding of immune cell metabolic reprogramming within the TME.
- To explore the link between metabolic changes and immune cell function in cancer.
- To suggest novel therapeutic and diagnostic strategies targeting immune responses in cancer.
Main Methods:
- Review of recent findings on immune cell metabolism in the TME.
- Analysis of the integration of immune and metabolic pathways in tumorigenesis.
- Discussion of the implications of metabolic reprogramming for cancer immunology.
Main Results:
- Cancer cells and immune cells exhibit significant metabolic reprogramming in the TME.
- This metabolic reprogramming is crucial for immune cell function and tumor immunology.
- Recent advances highlight the potential of targeting immune cell metabolism for cancer therapeutics.
Conclusions:
- Metabolic reprogramming of immune cells is a key feature of the tumor microenvironment.
- Targeting these metabolic pathways presents promising avenues for cancer diagnosis and therapy.
- Further research into immune metabolism in cancer can lead to innovative clinical treatments.
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